SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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114 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 231,531 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Ser Serina beta-Hydroxyalanine (S)-2-Amino-3-hydroxypropanoic acid Serinum (S)-Serine L-Serine alpha-Amino-beta-hydroxypropionic acid Serine
Brand Names	Essepna Hepatasol Primene 10% Smofkabiven Aminosyn II 7% With 50% Dextrose Renamin (amino Acids) Injection Aminosyn II 7% M In 10% Dextrose(dual Chamber) Nutrineal Pd4 ProSol Plenamine Periolimel 2.5% E Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn 8.5% 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II with Electrolytes Clinisol Aminosyn 8.5% Injection With Electrolytes Novamine FreAmine III Aminosyn II 5% Inj 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose ProcalAmine Aminosyn 5% Clinimix E Aminosyn-PF Aminosyn Kabiven 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II 10% With Electrolytes 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 20% Prosol Aminosyn II 7% With 10% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn 3.5% M Aminosyn II Olimel 7.6% Perikabiven HepatAmine Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 7% Travasol Aminosyn II In Dextrose Injection Smofkabiven Extra Nitrogen Aminosyn II 8.5% With 50% Dextrose Primene Aminosyn II with Electrolytes in Dextrose with Calcium Clinimix Aminosyn-PF 10% Aminosyn II in Dextrose Aminosyn-PF 7% Aminosyn II and Dextrose Aminosyn 10% W Electrolytes Aminosyn HF Vamin N 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex FreAmine HBC 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn Sulfite Free Olimel 4.4% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Olimel 5.7% E Smofkabiven Peripheral Olimel 4.4% E Olimel 3.3% E RenAmin Primene 10%-liq IV Premasol - sulfite-free (Amino Acid) Smofkabiven Electrolyte Free TrophAmine Synthamin 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 5.7% Olimel 7.6% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 8.5% Freamine III Aminosyn II 8.5% Injection Vamin 18 Electrolyte-free Aminosyn II 7% Injection
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01