9FRE | pdb_00009fre

CryoEM structure of human rho1 GABAA receptor in complex with THIP


Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.19 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.0 of the entry. See complete history


Literature

Cryo-EM structures of Rho1 GABAA receptors with antagonist and agonist drugs

Fan, C.Cowgill, J.Howard, R.J.Lindahl, E.

To be published.

Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Gamma-aminobutyric acid receptor subunit rho-1
A, B, C, D, E
479Homo sapiensMutation(s): 0 
Gene Names: GABRR1
UniProt & NIH Common Fund Data Resources
Find proteins for P24046 (Homo sapiens)
Explore P24046 
Go to UniProtKB:  P24046
PHAROS:  P24046
GTEx:  ENSG00000146276 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP24046
Sequence Annotations
Expand
  • Reference Sequence
Small Molecules
Ligands 7 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
NAG (Subject of Investigation/LOI)
Query on NAG

Download Ideal Coordinates CCD File 
AB [auth E]
BB [auth E]
DA [auth C]
EA [auth C]
G [auth A]
AB [auth E],
BB [auth E],
DA [auth C],
EA [auth C],
G [auth A],
H [auth A],
PA [auth D],
QA [auth D],
T [auth B],
U [auth B]
2-acetamido-2-deoxy-beta-D-glucopyranose
C8 H15 N O6
OVRNDRQMDRJTHS-FMDGEEDCSA-N
D12
Query on D12

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BA [auth B],
IB [auth E],
LA [auth C],
O [auth A],
XA [auth D]
DODECANE
C12 H26
SNRUBQQJIBEYMU-UHFFFAOYSA-N
D10
Query on D10

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AA [auth B]
CA [auth C]
HB [auth E]
KA [auth C]
N [auth A]
AA [auth B],
CA [auth C],
HB [auth E],
KA [auth C],
N [auth A],
OA [auth D],
Q [auth A],
R [auth B],
WA [auth D],
ZA [auth E]
DECANE
C10 H22
DIOQZVSQGTUSAI-UHFFFAOYSA-N
EI7
Query on EI7

Download Ideal Coordinates CCD File 
F [auth A],
NA [auth D],
P [auth A],
S [auth B],
YA [auth E]
4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one
C6 H8 N2 O2
ZXRVKCBLGJOCEE-UHFFFAOYSA-N
OCT
Query on OCT

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FB [auth E],
IA [auth C],
L [auth A],
UA [auth D],
Y [auth B]
N-OCTANE
C8 H18
TVMXDCGIABBOFY-UHFFFAOYSA-N
HEX
Query on HEX

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CB [auth E]
DB [auth E]
EB [auth E]
FA [auth C]
GA [auth C]
CB [auth E],
DB [auth E],
EB [auth E],
FA [auth C],
GA [auth C],
GB [auth E],
HA [auth C],
I [auth A],
J [auth A],
JA [auth C],
K [auth A],
M [auth A],
RA [auth D],
SA [auth D],
TA [auth D],
V [auth B],
VA [auth D],
W [auth B],
X [auth B],
Z [auth B]
HEXANE
C6 H14
VLKZOEOYAKHREP-UHFFFAOYSA-N
CL
Query on CL

Download Ideal Coordinates CCD File 
MA [auth C]CHLORIDE ION
Cl
VEXZGXHMUGYJMC-UHFFFAOYSA-M
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.19 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 
EM Software:
TaskSoftware PackageVersion
MODEL REFINEMENTPHENIX

Structure Validation

View Full Validation Report



Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
Swedish Research CouncilSweden2019-02433

Revision History  (Full details and data files)

  • Version 1.0: 2025-07-02
    Type: Initial release