Cryo-EM structures of Rho1 GABAA receptors with antagonist and agonist drugs
Fan, C., Cowgill, J., Howard, R.J., Lindahl, E.To be published.
Experimental Data Snapshot
wwPDB Validation   3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Gamma-aminobutyric acid receptor subunit rho-1 | 479 | Homo sapiens | Mutation(s): 0  Gene Names: GABRR1 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P24046 (Homo sapiens) Explore P24046  Go to UniProtKB:  P24046 | |||||
PHAROS:  P24046 GTEx:  ENSG00000146276  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P24046 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 5 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG (Subject of Investigation/LOI) Query on NAG | BB [auth E] CB [auth E] DA [auth C] EA [auth C] G [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N | |||
A1IFH Query on A1IFH | AB [auth E], CA [auth C], F [auth A], NA [auth D], R [auth B] | (S)-amino-3-hydroxybutanoic acid C4 H9 N O3 YQGDEPYYFWUPGO-VKHMYHEASA-N | |||
OCT Query on OCT | AA [auth B] BA [auth B] DB [auth E] EB [auth E] FA [auth C] | N-OCTANE C8 H18 TVMXDCGIABBOFY-UHFFFAOYSA-N | |||
HEX Query on HEX | FB [auth E] GB [auth E] HA [auth C] IA [auth C] IB [auth E] | HEXANE C6 H14 VLKZOEOYAKHREP-UHFFFAOYSA-N | |||
CL Query on CL | Q [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |
Funding Organization | Location | Grant Number |
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Swedish Research Council | Sweden | 2019-02433 |