9FRI | pdb_00009fri

CryoEM structure of human rho1 GABAA receptor in complex with (S)-GABOB in the primed state


Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.14 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.0 of the entry. See complete history


Literature

Cryo-EM structures of Rho1 GABAA receptors with antagonist and agonist drugs

Fan, C.Cowgill, J.Howard, R.J.Lindahl, E.

To be published.

Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Gamma-aminobutyric acid receptor subunit rho-1
A, B, C, D, E
479Homo sapiensMutation(s): 0 
Gene Names: GABRR1
UniProt & NIH Common Fund Data Resources
Find proteins for P24046 (Homo sapiens)
Explore P24046 
Go to UniProtKB:  P24046
PHAROS:  P24046
GTEx:  ENSG00000146276 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP24046
Sequence Annotations
Expand
  • Reference Sequence
Small Molecules
Ligands 5 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
NAG (Subject of Investigation/LOI)
Query on NAG

Download Ideal Coordinates CCD File 
BB [auth E]
CB [auth E]
DA [auth C]
EA [auth C]
G [auth A]
BB [auth E],
CB [auth E],
DA [auth C],
EA [auth C],
G [auth A],
H [auth A],
OA [auth D],
PA [auth D],
S [auth B],
T [auth B]
2-acetamido-2-deoxy-beta-D-glucopyranose
C8 H15 N O6
OVRNDRQMDRJTHS-FMDGEEDCSA-N
A1IFH
Query on A1IFH

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AB [auth E],
CA [auth C],
F [auth A],
NA [auth D],
R [auth B]
(S)-amino-3-hydroxybutanoic acid
C4 H9 N O3
YQGDEPYYFWUPGO-VKHMYHEASA-N
OCT
Query on OCT

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AA [auth B]
BA [auth B]
DB [auth E]
EB [auth E]
FA [auth C]
AA [auth B],
BA [auth B],
DB [auth E],
EB [auth E],
FA [auth C],
GA [auth C],
HB [auth E],
I [auth A],
J [auth A],
JA [auth C],
LA [auth C],
M [auth A],
MA [auth C],
O [auth A],
P [auth A],
QA [auth D],
RA [auth D],
U [auth B],
UA [auth D],
V [auth B],
WA [auth D],
XA [auth D],
Y [auth B],
YA [auth E],
ZA [auth E]
N-OCTANE
C8 H18
TVMXDCGIABBOFY-UHFFFAOYSA-N
HEX
Query on HEX

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FB [auth E]
GB [auth E]
HA [auth C]
IA [auth C]
IB [auth E]
FB [auth E],
GB [auth E],
HA [auth C],
IA [auth C],
IB [auth E],
K [auth A],
KA [auth C],
L [auth A],
N [auth A],
SA [auth D],
TA [auth D],
VA [auth D],
W [auth B],
X [auth B],
Z [auth B]
HEXANE
C6 H14
VLKZOEOYAKHREP-UHFFFAOYSA-N
CL
Query on CL

Download Ideal Coordinates CCD File 
Q [auth A]CHLORIDE ION
Cl
VEXZGXHMUGYJMC-UHFFFAOYSA-M
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.14 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

Structure Validation

View Full Validation Report



Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
Swedish Research CouncilSweden2019-02433

Revision History  (Full details and data files)

  • Version 1.0: 2025-07-02
    Type: Initial release